姓名：胡学博

联系方式：武汉华中农业大学狮子山南湖大道特1号第三综合楼A104房间

手机：1806-250-3982

电子邮箱：xuebohu@mail.hzau.edu.cn

职称：教授

职务：药用植物繁育与栽培国家地方联合工程研究中心、药用植物湖北省工程研究中心主任

主要研究方向：药用植物与药用真菌活性物质筛选、分离与应用；药用植物活性成分代谢与合成；植物次生代谢物酶工程；国际传统药物合作等。

教育背景

• 1997年毕业于华中农业大学，获植物保护学士学位。

• 1999年考入浙江大学攻读硕士学位，2001年被批准硕博连读，2004年毕业于浙江大学，获植物病理学博士学位。

  工作经历

  09/2012-现在，华中农业大学植物科技学院教授

• 高效抗炎、抗癌化合物筛选平台 我国传统中医中药为抗癌、抗炎积累了丰富的素材，但多数药物仍然有待揭示作用机理与深度开发。拟依托现代生物技术，结合现代医学，建立高效药物筛选平台进行活性物质作用机理研究。目前在研候选分子有抗炎症、糖尿病、肥胖病等候选药物分子。（重点）

• 药用植物次生物质的高效转化 中药活性物质具有巨大应用潜力，通过酶与化学转化，可能获得成药性更佳的分子。目前以中药雷公藤为主要研究对象。（重点）

• 药用真菌高效发酵与利用 重点针对灵芝、茯苓、牛樟芝等药食两用真菌，建立高效发酵技术，向产业化方向努力。（重点）

• 药用植物种质资源与药物代谢与合成 结合基因组学、转录组学等高通量生物信息知识，研究药用植物种质资源的分布规律，研究活性物质代谢生化与分子基础，并通过代谢工程在模式生物中进行生物合成。目前以茯苓基因组等为主要研究对象。（感兴趣）

• 药用植物生理与病理 探寻半夏、贝母夏眠机制。中药材病害。（感兴趣）

• 传统药物国际合作 以“一带一路”为契机，尽可能多地与各国同行建立紧密合作关系。目前联系国家和地区近50个，专家60余人（重点）

• 蛋白质与代谢工程 以植物肉为主的蛋白质工程。（业余级爱好）

12/2009-08/2912, 研究助理, 康乃尔大学，生物医学工程系（Research Associate, Biomedical Engineering Department, Cornell University）

11/2006-11/2009, 博士后，康乃尔大学，生物医学工程系（Postdoctoral Associate，Biomedical Engineering Department, Cornell University）

07/2004-10/2006, 助理研究员，中国科学院微生物研究所

专利

发表文章

2012年以后论文

1. Seifu Juneidi, Zengyan Gao, Huanran Yin, Nokwanda P. Makunga, Wei Chen, Sheng Hu, Xiaohua Li and Xuebo Hu*. Breaking the Summer Dormancy of Pinellia ternata by Introducing a Heat Tolerance Receptor-Like Kinase ERECTA Gene. Frontiers in Plant Sci., 2020 June 20, 11:780.

2. Xiaohua Li, Minhui Cao, Weibo Ma, Caihua Jia, Jinghuan Li, Mingxing Zhang, Changchun Liu, Zhenzhen Cao, Mohammad Omar Faruque, Xuebo Hu*. Annotation of genes involved in high level of dihydromyricetin production in vine tea (Ampelopsis grossedentata) by transcriptome analysis.  BMC Plant Bio. 2020 Mar 30;20(1):131.

3. Faruque MO^#, Feng G^#, Khan MNA, Barlow JW, Ankhi UR, Hu S, Kamaruzzaman M, Uddin SB*, Hu X*. Qualitative and quantitative ethnobotanical study of the Pangkhua community in Bilaichari Upazilla, Rangamati District, Bangladesh. J Ethnobiol Ethnomed. 2019 Feb 5;15(1):8.

4. Mohammad Omar Faruque, Umme Ruman, Ankhi, M.Kamaruzzaman, James W.Barlow, Bo Zhou, Ji Hao, Xinzhou Yang*, XueboHu* Chemical composition and antimicrobial activity of Congea tomentosa, an ethnomedicinal plant from Bangladesh.Industrial Crops and Products. Volume 141,1 December 2019, 111745.

5. Faruque MO, Uddin SB, Barlow JW, Hu S, Dong S, Cai Q, Li X, Hu X. Quantitative Ethnobotany of Medicinal Plants Used by Indigenous Communities in the Bandarban District of Bangladesh. Front Pharmacol. 2018 Feb 6;9:40

6. Zhang Q, Hu S, Wang K, Cui M, Li X, Wang M, Hu X. Engineering a yeast double-molecule carrier for drug screening. Artif Cells Nanomed Biotechnol. 2018;46(sup2):386-396.

7. Jafari M, Akram W, Pang Y, Ahmad A, Ahmed S, Yasin NA, Anjum T, Ali B, Hu X, Li X, Dong S, Cai Q, Ciprian M, Bielec M, Hu S, Sefidkon F, Hu X. Genetic diversity and biogeography of T. officinale inferred from multi locus sequence typing approach. PLoS One. 2018 Sep 18;13(9):e0203275.

8. Zhan C, Ahmed S, Hu S, Dong S, Cai Q, Yang T, Wang X, Li X, Hu X. Cytochrome P450 CYP716A254 catalyzes the formation of oleanolic acid from β-amyrin during oleanane-type triterpenoid saponins biosynthesis in Anemone flaccida. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1271-1277.

9. Ahmed S, Zhan C, Yang Y, Wang X, Yang T, Zhao Z, Zhang Q, Li X, Hu X. The Transcript Profile of a Traditional Chinese Medicine, Atractylodes lancea, Revealing Its Sesquiterpenoid Biosynthesis of the Major Active Components. PLoS One. 2016 Mar 18;11(3):e0151975.

10. Zhan C, Li X, Zhao Z, Yang T, Wang X, Luo B, Zhang Q, Hu Y, Hu X. Comprehensive Analysis of the Triterpenoid Saponins Biosynthetic Pathway in Anemone flaccida by Transcriptome and Proteome Profiling. Front Plant Sci. 2016 Jul 25;7:1094.

11. Ahmed S, Liu H, Ahmad A, Akram W, Abdelrahman EKN, Ran F, Ou W, Dong S, Cai Q, Zhang Q, Li X, Hu S, Hu X. Characterization of Anti-bacterial Compounds from the Seed Coat of Chinese Windmill Palm Tree (Trachycarpus fortunei).Front Microbiol. 2017 Oct 4;8:1894.

12. Hu Y, Ahmed S, Li J, Luo B, Gao Z, Zhang Q, Li X, Hu X. Improved ganoderic acids production in Ganoderma lucidum by wood decaying components. Sci Rep. 2017 Apr 19;7:46623.

13. Xin-Mei Zhao, Zhang-Qian Wang, Shao-Hua Shu, Wen-Juan Wang, Hai-Jie Xu, Young-Joon Ahn, Mo Wang*, Xuebo Hu*. Ethanol and Methanol Can Improve Huperzine A Production From Endophytic Colletotrichum gloeosporioides ES026. Plos One 2013, 8:e61777.

     

    2012年以前主要论文

14. Xuebo Hu, P. Saha, Xiaoyue Chen, Dogeun Kim, Mahesh Devarasetty, Raghavan Varadarajan, Moonsoo Jin. Cell Surface Assembly of HIV gp41 Six-Helix Bundles for Facile, Quantitative Measurements of Hetero-oligomeric Interactions. J. Am. Chem. Soc. 2012, 134:14642-14645.

2. Xuebo Hu, Sungkwon Kang, Craig Lefort, Minsoo Kim, Moonsoo Jin. Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies. Proc. Natl. Acad. Sci. U. S. A. 2010,107: 6252-6257.

1. Xuebo Hu, Sungkwon Kang, Xiaoyue Chen, Shoemaker CB, Moonsoo Jin. Yeast surface two-hybrid for quantitative in vivo detection of protein-protein interactions via the secretory pathway. J Biol Chem. 2009 12;284(24):16369-76.

2. Xuebo Hu, Huijuan Zhang, Guojun Li, Yuxia Yang, Zhong Zheng, Fengming Song. Ectopic expression of a rice protein phosphatase 2C gene OsBIPP2C2 in tobacco improves disease resistance. Plant Cell Rep. 2009, 28(6):985-95.

3. Xuebo Hu, Fengming Song, Zhong Zheng. Molecular characterization and expression analysis of a rice protein phosphatase 2C gene, OsBIPP2C1, and overexpression in transgenic tobacco conferred enhanced disease resistance and abiotic tolerance. Physiol Plant. 2006,127: 225-236.

4. Xuebo Hu, Fengming Song, Zhong Zheng. Molecular cloning and expression of rice OsTVLP1, encoding a protecin with similarity to TGF-belta receptor interacting proteins and vacuolar assembly Vam6p/Vps39p proteins. DNA Seq. 2006 17(2):152-158.

5. Xuebo Hu, Fengming Song, Zhong Zheng. Protein phosphatase 2C in higher plants: their classification, characteristics and function. 细胞生物学杂志 Chinese J Cell Biol 2005, 27(1):29-34.

6. Xuebo Hu, Wenda Zhu, Fengming Song. Molecular biology of vesicular-arbuscular mycorrhizal symbiosis. 西北农林科技大学学报J Northwest Sci-Tech Univ. Agri & For. 2001, 29 Supp1:114-119.

7. Xuebo Hu, Aocheng Cao. Advances in research on soil solarization and its use for control of soil transmitted diseases in fruit crops. 中国果树China Fruits 2001: 44-46.

8. Xuebo Hu, Aocheng Cao. Plant soil-borne diseases control by soil solarization. 世界农业World Agri. 2001, 265(5): 44- 47.